Decoded: How to reverse signs of ageing

July 21, 2018

New York:Scientists, including one of Indian origin, have found the way to reverse the action of wrinkled skin and hair loss which are considered as the hallmarks of ageing, in a mouse model.

The findings showed that, when a mutation leading to mitochondrial dysfunction is induced, the mouse develops wrinkled skin and extensive, visible hair loss in a matter of weeks.

However, when the mitochondrial function is restored by turning off the gene responsible for its dysfunction, the mouse returns to smooth skin and thick fur, indistinguishable from a healthy mouse of the same age.

According to the study authors, the decline in mitochondrial function among humans is seen during ageing, and can drive age-related diseases.

“This mouse model should provide an unprecedented opportunity for the development of preventive and therapeutic drug development strategies to augment the mitochondrial functions for the treatment of ageing-associated skin and hair pathology and other human diseases in which mitochondrial dysfunction plays a significant role,”said Keshav Singh, Professor at the University of Alabama at Birmingham, US.

For the study, published in the journal Cell Death & Disease, the team added antibiotic doxycycline — used to treat infections caused by bacteria and protozoa — to food or drinking water to induce the mutation which caused in depletion of mitochondrial DNA because the enzyme to replicate the DNA becomes inactive.

They found that, the mice showed gray hair, reduced hair density, hair loss, slowed movements and lethargy in four weeks. Wrinkled skin was seen four to eight weeks after induction of the mutation, and females had more severe skin wrinkles than males.

Reversal of the mutation restored mitochondrial function, as well as the skin and hair pathology.

However, little change was seen in other organs when the mutation was induced, suggesting an important role for mitochondria in skin compared to other tissues.

“It suggests that epigenetic mechanisms underlying mitochondria-to-nucleus cross-talk must play an important role in the restoration of normal skin and hair phenotype,” Singh said.

(IANS)

Fugitive Amritpal escaped on bike after changing clothes in gurdwara: Police

Chandigarh: Explaining how fugitive and Khalistan ideologue Amritpal Singh is still absconding while over 150 people have been arrested in connection with the March 18 crackdown, Punjab Police's Inspector General...

Nitish Kumar is ‘mentally unfit’: BJP MLA

Patna: BJP MLA Hari Bhushan Thakur on Tuesday said Bihar Chief Minister Nitish Kumar is "mentally unfit" and "misleading" 13 crore people of the state by giving "wrong" statements. He...

VHP to install flags with ‘Om’ at around 5 lakh houses

Prayagraj: The Vishwa Hindu Parishad (Kashi Prant) has decided to install saffron flags with 'Om' printed on them, at around five lakh houses in Kashi Prant comprising 17 districts of...

Indian students ask Sunak to clear their names in English test scandal

London: A group of international students, including many Indians, who had their visas revoked almost 10 years ago after accusations of cheating in English language tests in the UK, have...

Ruckus in Meghalaya Assembly over Governor’s speech in Hindi

Shillong, March 20 (IANS) Chaos erupted in the Meghalaya Assembly on the first day of the Budget session on Monday after Governor Phagu Chauhan delivered his speech in Hindi. Four members...

Azaan at DC office: K’taka BJP MLA Eshwarappa says its an ‘act of sedition’

Shivamogga (Karnataka): BJP MLA and former Karnataka Minister K.S. Eshwarappa on Monday trigerred a fresh controversy calling it an 'act of sedition', after a video of a Muslim youth performing...

Saudi King invites Iranian Prez to visit Riyadh

Tehran: Just over a week after Tehran and Riyadh agreed to restore diplomatic relations, Saudi Arabia's King Salman bin Abdulaziz Al Saud has invited Iranian President Ebrahim Raisi to visit...

Iran, Iraq sign security cooperation agreement

Tehran: Iran and Iraq have signed an agreement on security cooperation in Baghdad. The deal was signed on Sunday by visiting Secretary of Iran's Supreme National Security Council (SNSC) Ali...

UK envoy summoned after Khalistan supporters take down Tricolour at Indian High Commission in London

New Delhi: The Ministry of External Affairs (MEA) late on Sunday summoned the senior-most UK diplomat in India to convey its strong protest after some pro-Khalistani groups allegedly took down...

Atiq Ahmad’s wife, sons to be named as gang members

Prayagraj: In a first, Shaista Parveen , wife of mafia-turned-politician Atiq Ahmad, and their three sons will now be named as members of his gang registered as IS-227 in police...

Imran booked on terror charges over clashes in Islamabad

Islamabad: Pakistan Tehreek-e-Insaf (PTI) Chairman Imran Khan and other PTI leaders were on Sunday booked on terror charges for clashes between the police and party activists outside the Islamabad judicial...

Kuwait court nullifies 2022 election results, reinstates previous Parliament

Kuwait City: Kuwait's Constitutional Court on Sunday annulled the 2022 National Assembly and brought back the 2020 Parliament, the media reported. The ruling, which took immediate effect, saw members of...

Read Previous

Will fight LS polls alone in Bengal: Mamata

Read Next

Woman dies in Los Angeles store siege, gunman nabbed

Leave a Reply

Your email address will not be published.

WP2Social Auto Publish Powered By : XYZScripts.com